Shapiro founded Seeds of Change in 1989. He was sold to Mars Inc. in 1997 and took on the role of Senior Scientist in plant science and agroforestry/agroecology. He is Adjunct Professor in the College of Agriculture and Environmental Sciences at the University of California, Davis and leads the Multi-Disciplinary Research Unit. He has been a university professor, Fulbright Scholar, Ford Foundation Fellow, and has won the National Endowment for the Humanities Award. He is working with Google X and other groups on a project to end human stunting through better nutrition worldwide.